Antigen Delivery Systems: Immunological and Technological by Bruno Gander, Hans P Merkle, Giampietro Corradin

By Bruno Gander, Hans P Merkle, Giampietro Corradin

This article provides an updated review of modern advancements during this box, stories new tendencies in vaccine improvement courses, and emphasizes the necessities and significance of assorted vaccine supply structures.

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Extra resources for Antigen Delivery Systems: Immunological and Technological Issues (Drug Targeting and Delivery)

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Mol. , 33, 387–397. K.

This mode of antigen recognition consequently depends on the sequence of the determinants rather than the tridimensional structure of the antigens. Thus, determinants which are buried in a folded polypeptide can nevertheless be released for recognition by T cells. While antibodies are intended to bind antigens encountered in the extracellular milieu, T lymphocytes have the capacity to detect antigens taken up by other cells, as well as antigens residing in cells. That antigen recognition relies on different mechanisms decreases the likelihood that a pathogen could succeed to deceive the immune system.

The membrane-distal domains, the α1 and β1, which contain most of the polymorphic residues between alleles, constitute the peptide binding site. This structure is formed by a floor of 8 βplated sheets on which lay two α-helices. The antigen fragments are bound in the groove between the helices (Madden, 1995). , 1993). , (1988) on the basis of a similar arrangement of clusters of polymorphic and conserved residues between class I and class II polypeptides, the structures of class I and class II MHC heterodimers are closely related.

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