Annual Review of Immunology Volume 29 2011 by Annual Reviews

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Tumanov AV, Grivennikov SI, Shakhov AN, Rybtsov SA, Koroleva EP, et al. 2003. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol. Rev. 195:106–16 47. Cupedo T, Jansen W, Kraal G, Mebius RE. 2004. Induction of secondary and tertiary lymphoid structures in the skin. Immunity 21:655–67 48. Gonzalez M, Mackay F, Browning JL, Kosco-Vilbois MH, Noelle RJ. 1998. The sequential role of lymphotoxin and B cells in the development of splenic follicles. J. Exp. Med. 187:997–1007 49.

Jenkins MK, Chu HH, McLachlan JB, Moon JJ. 2010. On the composition of the preimmune repertoire of T cells specific for peptide-major histocompatibility complex ligands. Annu. Rev. Immunol. 28:275–94 Roozendaal · Mebius Annu. Rev. Immunol. 29:23-43. org by University of Iowa on 05/26/11. For personal use only. IY29CH02-Mebius ARI 7 February 2011 20:12 103. Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D, Rudensky AY. 2004. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

Rev. Immunol. 29:23-43. org by University of Iowa on 05/26/11. For personal use only. IY29CH02-Mebius ARI 7 February 2011 20:12 DCs does not reduce the amount of CXCL13 produced in these structures, which points to additional cellular sources of CXCL13 (44). In general, tertiary lymphoid structures resemble SLOs in composition and organization, although differences have been noted. For instance, lymphatic vessels are not regularly connected to tertiary lymphoid structures (115). Also, MRCs are reported to be absent in tertiary lymphoid structures in the stomach (34a), although this will have to be verified in organized lymphoid tissues that develop in other chronically inflamed tissues and autoimmune diseases.

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