Animal Models in Eye Research by Panagiotis Antonios Tsonis

By Panagiotis Antonios Tsonis

The attention is a fancy sensory organ, which allows visible conception of the realm. hence the attention has numerous tissues that do diversified initiatives. probably the most easy elements of eye functionality is the sensitivity of cells to gentle and its transduction although the optic nerve to the mind. diversified organisms use alternative ways to accomplish those projects. during this feel, eye functionality turns into an important evolutionary element in addition. This booklet provides the various animal versions which are normal for eye study and their forte in comparing varied points of eye improvement, evolution, body structure and disorder. * offers details at the significant animal versions utilized in eye learn together with invertebrates and vertebrates* presents researchers with info had to make a choice from version organisms* comprises an introductory bankruptcy at the types of eyes, stressing attainable universal molecular equipment

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In strong so alleles, the optic lobe primordium does not invaginate and precursors of the larval eye are not specified. , 1994). Optix is expressed anterior to the furrow, whereas so expression is much broader (Seimiya and Gehring, 2000). Interestingly, the two 6/11/2008 3:13:32 PM THE RETINAL DETERMINATION NETWORK (RDN) PROVIDES THE BASIS FOR EYE FORMATION Six genes seem to conduct very distinct functions in Drosophila. so only has weak ability to induce ectopic eyes, whereas Optix ectopic expression is more efficient and occurs in ey-independent manner, in contrast to so.

The antagonistic action of Notch and EGFR is required to specify the antennal and eye part in the eye-antennal imaginal disc (see above). In the context of furrow formation Notch and EGFR signaling act synergistically to promote furrow initiation (Kumar and Moses, 2001b). Temperature shift experiments indicate that Dpp, EGFR, and Hh signaling are required for birth of the morphogenetic furrow. The progressive movement of the morphogenetic furrow across the epithelium is a reiterative process, which also uses Hh, Dpp, and Notch signaling.

Indd 32 so and optix belong to the Six gene family characterized by a Six domain that mediates protein–protein interactions, and has a DNA binding homeodomain. The vertebrate so homolog Six1 is involved in regulating cell proliferation, but does not seem to affect eye development, whereas the optix homologs Six3/Six6 act as transcriptional repressors that are important for eye and brain development. so is required for the development of the entire visual system but no optix mutants have been published so far.

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