Analysis of Deterministic Cyclic Gene Regulatory Network by Mehmet Eren Ahsen, Hitay Özbay, Silviu-Iulian Niculescu

By Mehmet Eren Ahsen, Hitay Özbay, Silviu-Iulian Niculescu

This short examines a deterministic, ODE-based version for gene regulatory networks (GRN) that includes nonlinearities and time-delayed suggestions. An introductory bankruptcy presents a few insights into molecular biology and GRNs. The mathematical instruments useful for learning the GRN version are then reviewed, specifically Hill services and Schwarzian derivatives. One bankruptcy is dedicated to the research of GRNs lower than unfavorable suggestions with time delays and a different case of a homogenous GRN is taken into account. Asymptotic balance research of GRNs less than optimistic suggestions is then thought of in a separate bankruptcy, during which stipulations resulting in bi-stability are derived. Graduate and complex undergraduate scholars and researchers up to the mark engineering, utilized arithmetic, platforms biology and artificial biology will locate this short to be a transparent and concise advent to the modeling and research of GRNs.

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0; R/ denotes the set of real valued continuous functions defined on the interval Œ ; 0. a/, for a 2 Œ ; 0. 3). 8). The questions of whether we have a unique or multiple equilibrium points, and whether these points are stable or not, are the subject of the remaining chapters. 2 Analysis of the Linearized Model Let xeq D Œx1 ; : : : ; xn T be an equilibrium point of the system. 8, we obtain the following result. 1. 5). Proof. 5). 8, we conclude that h has as many fixed point as g. But each fixed point of h is an equilibrium point of the system, which concludes the proof.

2. x/ < 0. 3. bx/, then S(h(x))< 0. 1 Classification of Functions with Negative Schwarzian Derivatives 29 In the sequel, we try to classify functions with negative Schwarzian derivatives. Next result helps this endeavor. 1. 0; 1/ with a < b. 11) Proof. For the first part of Lemma, suppose on the contrary that there exist positive constants a < b such that h0 is constant in Œa; b. c/ D 0; which is a contradiction. Therefore, h0 cannot be constant in any subinterval of RC . d / > 0. x2 / for all x 2 I .

Hint: You may use the matrix inversion lemma. k Problem 2. sC4/ , with k 2 R. s/e s D 0 is stable independent of delay 0. 10 Problem 3. s/e D 0 is stable for all 2 Œ0 ; max /. Problem 4. t / / ; where > 0. Find the unique equilibrium point of this system, and obtain the linearized system around this equilibrium. Problem 5. x/ D 2 . 0:1Cx 2 //; Determine all equilibrium points of this system. Chapter 3 Functions with Negative Schwarzian Derivatives Abstract This chapter is devoted to the analysis on functions with NSD (negative Schwarzian derivatives).

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