Across Coveted Lands; or, A Journey from Flushing (Holland) by Arnold Henry Savage 1865-1924 Landor

By Arnold Henry Savage 1865-1924 Landor

This Elibron Classics publication is a facsimile reprint of a 1902 version via Macmillan & Co., Ltd., London.

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Across Coveted Lands; or, A Journey from Flushing (Holland) to Calcutta, Overland: Volume 2

This Elibron Classics booklet is a facsimile reprint of a 1902 variation via Macmillan & Co. , Ltd. , London.

Additional resources for Across Coveted Lands; or, A Journey from Flushing (Holland) to Calcutta, Overland: Volume 2

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From this perspective, the approach offers some progress in achieving a more systematic and structurally contextual description of enzyme function than has previously been available. This is because a definition of enzyme function in the superfamily context more precisely reflects the physical reality of protein evolution—that protein function evolves through changes in protein structure—than do earlier definitions that were developed without benefit of structural information. C. system (Bairoch, 1999) designates the members of the enolase, VOC, and HAD superfamilies.

B. Tandem Duplication Duplication of genes or gene fragments in tandem is one method observed in nature to evolve new function. Its occurrence in so many proteins clearly supports its advantages: (1) increased stability, (2) new cooperative functions, (3) formation of a binding site in a cleft, (4) production of multiple binding sites in series resulting in more efficient or specific binding, and (5) growth of long repetitive structures in modular proteins (McLachlan, 1987). The two possible evolutionary outcomes for such duplications are domains that function in isolation and domains that interact.

B. The HAD Superfamily: A Common Chemistry for Hire? The HAD superfamily, again, like the enolase and VOC superfamilies, represents highly divergent enzymes catalyzing many different functions. Again, the common active site machinery can be correlated with a common functional step in all the member mechanisms. Of the superfamilies represented in Table I, the sequences of the HAD superfamily are the most divergent. , 1998). , 1997) with that of a recently solved structure for a phosphonatase (M.

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